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In 1971, Dr. O. Carl Simonton, a radiologist at the University of Texas met a 61-year old patient who had throat cancer that had progressed so far that the man could hardly swallow and he only weighed 98 pounds. His prognosis was very poor with only a 5% of surviving 5 years after treatment. In any case, the patient was so weak that it seemed highly unlikely that he would respond well to radiation, the standard therapy for his condition.